Normal mouse heart pictured on the left compared to the one of the right, which has cardiac hypertrophy
Cardiac stress that’s caused by a heart attack or high blood pressure will frequently lead to pathological heart growth and eventually lead to heart failure. Researchers have discovered that two micro-scale RNA molecules, microRNA miR-212 and miR-132 play a role in this detrimental development in mice. When these molecules were inhibited, the mice were protected against pathological heart growth and failure. Researchers hope to adapt these findings and develop therapeutic approaches that would work in humans.
Read more @ SciTechDaily
Contrary to the skin and liver, damaged hearts rarely heal themselves but there is new research that might raise hope for cell therapies. It’s been recently shown that heart muscle cells differentiated from human embryonic stem cell could be reintegrated into an existing heart muscle.
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