Telomerase Gene Therapy Extends Mouse Lifespan by 24%


Inducing cells to express telomerase, the enzyme which is supposed to slow down the metabolic clock, has enabled researchers boost the lifespan of mouse by 24% with a single treatment.

Read more @ SciTechDaily

4 Responses to “Telomerase Gene Therapy Extends Mouse Lifespan by 24%”

  1. 1 bluewoodtree December 1, 2012 at 17:00

    Sure, but what about increased cancer risk? I mean, you are messing up with apoptosis regulation…

    • 2 range December 2, 2012 at 03:57

      The results come from a cancer research group, and at least in mouse models, there seemed to be no increased risk of cancer, but how this will translate into humans is another question.

      • 3 bluewoodtree December 2, 2012 at 06:45

        I was just thinking about when they discovered years ago that suppressed telomerase activity decreases cancer, thus it sounds a little bit controversial to me. I mean, if the cell lives longer by counter-acting the telomere-shortening it will also accumulate all sorts of mutations, which will eventually lead to cancer. Maybe this is not such a big problem in mice, because their average life span is so much shorter than for humans.

  2. 4 range December 2, 2012 at 14:19

    That’s probably one of the reasons why telomerase-based therapies were abandoned in the past.

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