Inhibition of MicroRNAs in Mice Can Attenuate Cardiovascular Stress

cardiac-hypertrophy-mice
Normal mouse heart pictured on the left compared to the one of the right, which has cardiac hypertrophy

Cardiac stress that’s caused by a heart attack or high blood pressure will frequently lead to pathological heart growth and eventually lead to heart failure. Researchers have discovered that two micro-scale RNA molecules, microRNA miR-212 and miR-132 play a role in this detrimental development in mice. When these molecules were inhibited, the mice were protected against pathological heart growth and failure. Researchers hope to adapt these findings and develop therapeutic approaches that would work in humans.

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