This series is based on the Southern Vampire Mysteries books by Charlaine Harris. It tells the story of how humans and vampires co-exist in a small southern town. Personally, I’ve never read the books, so I don’t know how accurate the adaptation is. However, it is quite interesting. It’s a good twist on the mythos.
There are loads of vampire shows out there. Most recently, Moonlight was canceled from CBS. Some of them are successful, others aren’t. The pilot was interesting. I’ve never seen a show explore the relationship between vampires and humans.